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HLA Class II Allele Analyses Implicate Common Genetic Components in Type 1 and Non–Insulin-Treated Type 2 Diabetes

Jacobi, Thomas ; Massier, Lucas ; Klöting, Nora ; Horn, Katrin ; Schuch, Alexander ; Ahnert, Peter ; Engel, Christoph ; Löffler, Markus ; Burkhardt, Ralph ; Thiery, Joachim ; Tönjes, Anke ; Stumvoll, Michael ; Blüher, Matthias ; Doxiadis, Ilias ; Scholz, Markus ; Kovacs, Peter


Context: Common genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of HLA class II genes in the pathophysiology of type 1 diabetes, the aim of the present study was to test the association of high density imputed human leukocyte antigen (HLA) genotypes with type 2 diabetes. Objectives and Design: Three cohorts ...


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