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CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation

Dragon, Anna Christina ; Zimmermann, Katharina ; Nerreter, Thomas ; Sandfort, Deborah ; Lahrberg, Julia ; Klöß, Stephan ; Kloth, Christina ; Mangare, Caroline ; Bonifacius, Agnes ; Tischer-Zimmermann, Sabine ; Blasczyk, Rainer ; Maecker-Kolhoff, Britta ; Uchanska-Ziegler, Barbara ; Abken, Hinrich ; Schambach, Axel ; Hudecek, Michael ; Eiz-Vesper, Britta



Abstract

Background Immunosuppressive therapy or T-cell depletion in transplant patients can cause uncontrolled growth of Epstein-Barr virus (EBV)-infected B cells resulting in post-transplant lymphoproliferative disease (PTLD). Current treatment options do not distinguish between healthy and malignant B cells and are thereby often limited by severe side effects in the already immunocompromised patients. ...

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