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Anti-BAFF Treatment Interferes With Humoral Responses in a Model of Renal Transplantation in Rats

Steines, Louisa ; Poth, Helen ; Schuster, Antonia ; Geissler, Edward K. ; Amann, Kerstin ; Banas, Bernhard ; Bergler, Tobias



Zusammenfassung

Background. B-cell-activating factor (BAFF) is associated with donor-specific antibodies (DSA) and poorer outcomes after renal transplantation (RTx). We examined the effects of anti-BAFF treatment on B cells, expression of costimulatory molecules and cytokines, germinal centers (GCs), and DSA formation in an RTx model in rats. Methods. Anti-BAFF antibody was injected on days 3, 17, 31, and 45 ...

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