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Collective cancer invasion forms an integrin-dependent radioresistant niche

Friedl, Peter ; Kissler, Stephan ; Geissler, Edward K. ; Hoffman, Robert M. ; Flentje, Michael ; Hirschberg, Markus ; Koehl, Gudrun E. ; Flucke, Uta ; Veelken, Cornelia ; Kaiser, Fabian M. P. ; Vullings, Manon ; Alexander, Stephanie ; Haeger, Anna



Abstract

Cancer fatalities result from metastatic dissemination and therapy resistance, both processes that depend on signals from the tumor microenvironment. To identify how invasion and resistance programs cooperate, we used intravital microscopy of orthotopic sarcoma and melanoma xenografts. We demonstrate that these tumors invade collectively and that, specifically, cells within the invasion zone ...

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