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Aberrant DNA methylation patterns in microsatellite stable human colorectal cancers define a new marker panel for the CpG island methylator phenotype

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Gebhard, Claudia ; Mulet‐Lazaro, Roger ; Glatz, Dagmar ; Schwarzfischer‐Pfeilschifter, Lucia ; Schirmacher, Peter ; Gaedcke, Jochen ; Weichert, Wilko ; Reuschel, Edith ; Dietmaier, Wolfgang ; Rehli, Michael
License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 21 Oct 2021 06:23

This publication is part of the DEAL contract with Wiley.


A distinct group of colorectal carcinomas (CRCs) referred to as the “CpG island methylator phenotype” (CIMP) shows an extremely high incidence of de novo DNA methylation and may share common pathological, clinical or molecular features. However, there is limited consensus about which CpG islands (CGIs) define a CIMP, particularly in microsatellite stable (MSS) carcinomas. To study this phenotype ...


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