Aberrant DNA methylation patterns in microsatellite stable human colorectal cancers define a new marker panel for the CpG island methylator phenotype

URN to cite this document:: urn:nbn:de:bvb:355-epub-508412
DOI to cite this document:: 10.5283/epub.50841

Gebhard, Claudia

; Mulet‐Lazaro, Roger ; Glatz, Dagmar ; Schwarzfischer‐Pfeilschifter, Lucia ; Schirmacher, Peter ; Gaedcke, Jochen ; Weichert, Wilko ; Reuschel, Edith ; Dietmaier, Wolfgang ; Rehli, Michael

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Date of publication of this fulltext: 21 Oct 2021 06:23

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Abstract

A distinct group of colorectal carcinomas (CRCs) referred to as the “CpG island methylator phenotype” (CIMP) shows an extremely high incidence of de novo DNA methylation and may share common pathological, clinical or molecular features. However, there is limited consensus about which CpG islands (CGIs) define a CIMP, particularly in microsatellite stable (MSS) carcinomas. To study this phenotype ...