Abstract
Incompatible transfusions in patients with antibodies to red blood cells (RBC) are usually omitted. Anti-M is one of the most frequent irregular antibodies to RBC. The relevance of this cold reactive antibody remains usually obscure.
We report on a M and N positive patient, who got transplanted with peripheral blood stem cells containing 319 mL plasma with an antibody to M that was clearly ...
Abstract
Incompatible transfusions in patients with antibodies to red blood cells (RBC) are usually omitted. Anti-M is one of the most frequent irregular antibodies to RBC. The relevance of this cold reactive antibody remains usually obscure.
We report on a M and N positive patient, who got transplanted with peripheral blood stem cells containing 319 mL plasma with an antibody to M that was clearly reactive at 4 °C in saline milieu and at 37 °C by indirect antiglobulin testing.
The patient did not show any clinical signs of reaction during or after the transplantation, and hemolysis parameters remained largely unsuspicious: LDH was before, 2 h, and 1 day after transplantation 161 U/L, 169 U/L, and 185 U/L, respectively, and haptoglobin before, 2 h, and 1 day after transplantation was 134 mg/dL, 136 mg/dL, and 133 mg/dL, respectively. Engraftment was regular, and no RBC transfusion was required.
This case illustrates that an incompatibility due to a limited amount of a coldreactive anti-M may be tolerated.
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