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Anti-HLA antibodies in pooled human serum do not prevent development of human regulatory macrophages from monocytes in culture

Hutchinson, James A. ; Riquelme, Paloma ; Bach, Christian ; Geissler, Edward K. ; Ahrens, Norbert



Zusammenfassung

Background: A GMP-compliant process for manufacturing a medicinal cellbased product, known as Mreg_UKR, containing human regulatory macrophages (Mreg) has been established. Mreg_UKR is currently being investigated in a Phase-I/II trial as a means to safely reduce maintenance immunosuppression in kidney transplant recipients. Partway into this study, manufacturing failure occurred in 3 ...

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