Extracellular citrate and metabolic adaptations of cancer cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-512720
DOI to cite this document:: 10.5283/epub.51272

Parkinson, E. Kenneth ; Adamski, Jerzy ; Zahn, Grit ; Gaumann, Andreas ; Flores-Borja, Fabian ; Ziegler, Christine ; Mycielska, Maria E.

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Date of publication of this fulltext: 23 Dec 2021 08:34

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Abstract

It is well established that cancer cells acquire energy via the Warburg effect and oxidative phosphorylation. Citrate is considered to play a crucial role in cancer metabolism by virtue of its production in the reverse Krebs cycle from glutamine. Here, we review the evidence that extracellular citrate is one of the key metabolites of the metabolic pathways present in cancer cells. We review the ...