A Polymorphism of Bactericidal/Permeability-Increasing Protein Affects Its Neutralization Efficiency towards Lipopolysaccharide

URN to cite this document:: urn:nbn:de:bvb:355-epub-519066
DOI to cite this document:: 10.5283/epub.51906

Ederer, Katharina U. ; Holzinger, Jonas M. ; Maier, Katharina T. ; Zeller, Lisa ; Werner, Maren ; Toelge, Martina ; Gessner, André

; Bülow, Sigrid

Preview

License: Creative Commons Attribution 4.0
PDF - Published Version
(1MB)

Date of publication of this fulltext: 09 Mar 2022 17:16

Alternative links to fulltext:DOI Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

Gram-negative sepsis driven by lipopolysaccharide (LPS) has detrimental outcomes, especially in neonates. The neutrophil-derived bactericidal/permeability-increasing protein (BPI) potently neutralizes LPS. Interestingly, polymorphism of the BPI gene at position 645 (rs4358188) corresponds to a favorable survival rate of these patients in the presence of at least one allele 645 A as opposed to 645 ...