Microbiological and ultrastructural evaluation of bacteriophage 191219 against planktonic, intracellular and biofilm infection with Staphylococcus aureus

URN to cite this document:: urn:nbn:de:bvb:355-epub-520781
DOI to cite this document:: 10.5283/epub.52078

Mannala, Gopala‐Krishna

; Rupp, Markus

; Walter, Nike

; Brunotte, Maximilian ; Alagboso, Francisca

; Docheva, Denitsa

; Brochhausen, Christoph

; Alt, Volker

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Date of publication of this fulltext: 22 Apr 2022 18:50

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Abstract

Infections of orthopaedic implants, such as fracture fixation devices and total-joint prostheses, are devastating complications. Staphylococcus aureus (S. aureus) is a predominant pathogen causing orthopaedic-implant biofilm infections that can also internalise and persist in osteoblasts, thus resisting antibiotic therapy. Bacteriophages are a promising alternative treatment approach. However, ...