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Microbiological and ultrastructural evaluation of bacteriophage 191219 against planktonic, intracellular and biofilm infection with Staphylococcus aureus

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Mannala, Gopala‐Krishna ; Rupp, Markus ; Walter, Nike ; Brunotte, Maximilian ; Alagboso, Francisca ; Docheva, Denitsa ; Brochhausen, Christoph ; Alt, Volker
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Apr 2022 18:50


Infections of orthopaedic implants, such as fracture fixation devices and total-joint prostheses, are devastating complications. Staphylococcus aureus (S. aureus) is a predominant pathogen causing orthopaedic-implant biofilm infections that can also internalise and persist in osteoblasts, thus resisting antibiotic therapy. Bacteriophages are a promising alternative treatment approach. However, ...


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