Donor-But Not Recipient-Derived Cells Produce Collagen-1 in Chronically Rejected Cardiac Allografts

URN to cite this document:: urn:nbn:de:bvb:355-epub-520892
DOI to cite this document:: 10.5283/epub.52089

Balam, Saidou

; Buchtler, Simone ; Winter, Frederike ; Schmidbauer, Kathrin ; Neumayer, Sophia ; Talke, Yvonne ; Renner, Kerstin ; Geissler, Edward K.

; Mack, Matthias

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Date of publication of this fulltext: 07 Apr 2022 04:57

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Abstract

Fibrosis is a prominent feature of chronic allograft rejection, caused by an excessive production of matrix proteins, including collagen-1. Several cell types produce collagen-1, including mesenchymal fibroblasts and cells of hematopoietic origin. Here, we sought to determine whether tissue-resident donor-derived cells or allograft-infiltrating recipient-derived cells are responsible for ...