Rifampicin restores extracellular organic matrix formation and mineralization of osteoblasts after intracellular Staphylococcus aureus infection

URN to cite this document:: urn:nbn:de:bvb:355-epub-530006
DOI to cite this document:: 10.5283/epub.53000

Alagboso, Francisca I. ; Mannala, Gopala K. ; Walter, Nike

; Docheva, Denitsa

; Brochhausen, Christoph

; Alt, Volker

; Rupp, Markus

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 10 Oct 2022 13:55

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Abstract

Aims Bone regeneration during treatment of staphylococcal bone infection is challenging due to the ability of Staphylococcus aureus to invade and persist within osteoblasts. Here, we sought to determine whether the metabolic and extracellular organic matrix formation and mineralization ability of S. aureus- infected human osteoblasts can be restored after rifampicin (RMP) therapy. Methods The ...