Influence of the Peripheral Nervous System on Murine Osteoporotic Fracture Healing and Fracture-Induced Hyperalgesia

URN to cite this document:: urn:nbn:de:bvb:355-epub-537804
DOI to cite this document:: 10.5283/epub.53780

Wank, Isabel ; Niedermair, Tanja ; Kronenberg, Daniel ; Stange, Richard ; Brochhausen, Christoph

; Hess, Andreas ; Grässel, Susanne

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 15 Feb 2023 12:23

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Abstract

Osteoporotic fractures are often linked to persisting chronic pain and poor healing outcomes. Substance P (SP), α-calcitonin gene-related peptide (α-CGRP) and sympathetic neurotransmitters are involved in bone remodeling after trauma and nociceptive processes, e.g., fracture-induced hyperalgesia. We aimed to link sensory and sympathetic signaling to fracture healing and fracture-induced ...