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Glycan masking of a non-neutralising epitope enhances neutralising antibodies targeting the RBD of SARS-CoV-2 and its variants

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Carnell, George W. ; Billmeier, Martina ; Vishwanath, Sneha ; Suau Sans, Maria ; Wein, Hannah ; George, Charlotte L. ; Neckermann, Patrick ; Del Rosario, Joanne Marie M. ; Sampson, Alexander T. ; Einhauser, Sebastian ; Aguinam, Ernest T. ; Ferrari, Matteo ; Tonks, Paul ; Nadesalingam, Angalee ; Schütz, Anja ; Huang, Chloe Qingzhou ; Wells, David A. ; Paloniemi, Minna ; Jordan, Ingo ; Cantoni, Diego ; Peterhoff, David ; Asbach, Benedikt ; Sandig, Volker ; Temperton, Nigel ; Kinsley, Rebecca ; Wagner, Ralf ; Heeney, Jonathan L.
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Date of publication of this fulltext: 06 Mar 2023 15:32


The accelerated development of the first generation COVID-19 vaccines has saved millions of lives, and potentially more from the long-term sequelae of SARS-CoV-2 infection. The most successful vaccine candidates have used the full-length SARS-CoV-2 spike protein as an immunogen. As expected of RNA viruses, new variants have evolved and quickly replaced the original wild-type SARS-CoV-2, leading ...


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