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CAR T cell therapy becomes CHIC: “cytokine help intensified CAR” T cells

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Thomas, Simone ; Abken, Hinrich
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Date of publication of this fulltext: 24 Mar 2023 07:49


Chimeric antigen receptors (CARs) in the canonical “second generation” format provide two signals for inducing T cell effector functions; the primary “signal-1” is provided through the TCR CD3ζ chain and the “signal-2” through a linked costimulatory domain to augment activation. While therapy with second generation CAR T cells can induce remissions of leukemia/lymphoma in a spectacular fashion, ...


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