KCNE1 does not shift TMEM16A from a Ca2+ dependent to a voltage dependent Cl- channel and is not expressed in renal proximal tubule

URN to cite this document:: urn:nbn:de:bvb:355-epub-544861
DOI to cite this document:: 10.5283/epub.54486

Talbi, Khaoula ; Ousingsawat, Jiraporn

; Centeio, Raquel ; Schreiber, Rainer

; Kunzelmann, Karl

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 17 Jul 2023 12:40

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Abstract

The TMEM16A (ANO1) Cl- channel is activated by Ca2+ in a voltage-dependent manner. It is broadly expressed and was shown to be also present in renal proximal tubule (RPT). KCNQ1 is an entirely different K+ selective channel that forms the cardiac IKS potassium channel together with its ß-subunit KCNE1. Surprisingly, KCNE1 has been claimed to interact with TMEM16A, and to be required for ...