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Intestinal IgA positive plasma cells are highly sensitive indicators of alloreaction early after allogeneic transplantation and associate with both, graft-<i>versus-</i>host disease and relapse related mortality

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Scheidler, Lucia ; Hippe, Katrin ; Ghimire, Sakhila ; Weber, Daniela ; Weber, Markus ; Meedt, Elisabeth ; Hoffmann, Petra ; Lehn, Petra ; Burkhardt, Ralph ; Mamilos, Andreas ; Edinger, Matthias ; Wolff, Daniel ; Poeck, Hendrik ; Evert, Matthias ; Gessner, André ; Herr, Wolfgang ; Holler, Ernst
Date of publication of this fulltext: 29 Aug 2023 15:04


Intestinal IgA is strongly involved in microbiota homeostasis. Since microbiota disruption is a major risk factor of acute GvHD, we addressed the kinetics of intestinal IgA-positive (IgA+) plasma cells by immunohistology in a series of 430 intestinal biopsies obtained at a median of 1,5 months after allogeneic stem cell transplantation from 115 patients (pts) at our center. IgA+ plasma cells were ...


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