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Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy

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Heidegger, Simon ; Stritzke, Florian ; Dahl, Sarah ; Daßler-Plenker, Juliane ; Joachim, Laura ; Buschmann, Dominik ; Fan, Kaiji ; Sauer, Carolin M. ; Ludwig, Nils ; Winter, Christof ; Enssle, Stefan ; Li, Suqi ; Perl, Markus ; Görgens, André ; Haas, Tobias ; Orberg, Erik Thiele ; Göttert, Sascha ; Wölfel, Catherine ; Engleitner, Thomas ; Cortés-Ciriano, Isidro ; Rad, Roland ; Herr, Wolfgang ; Giebel, Bernd ; Ruland, Jürgen ; Bassermann, Florian ; Coch, Christoph ; Hartmann, Gunther ; Poeck, Hendrik
Date of publication of this fulltext: 19 Sep 2023 10:58


Tumor-derived extracellular vesicles (EVs) have been associated with immune evasion and tumor progression. We show that the RNA-sensing receptor RIG-I within tumor cells governs biogenesis and immunomodulatory function of EVs. Cancer-intrinsic RIG-I activation releases EVs, which mediate dendritic cell maturation and T cell antitumor immunity, synergizing with immune checkpoint blockade. Intact ...


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