Go to content
UR Home

Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy

URN to cite this document:
urn:nbn:de:bvb:355-epub-547231
DOI to cite this document:
10.5283/epub.54723
Heidegger, Simon ; Stritzke, Florian ; Dahl, Sarah ; Daßler-Plenker, Juliane ; Joachim, Laura ; Buschmann, Dominik ; Fan, Kaiji ; Sauer, Carolin M. ; Ludwig, Nils ; Winter, Christof ; Enssle, Stefan ; Li, Suqi ; Perl, Markus ; Görgens, André ; Haas, Tobias ; Orberg, Erik Thiele ; Göttert, Sascha ; Wölfel, Catherine ; Engleitner, Thomas ; Cortés-Ciriano, Isidro ; Rad, Roland ; Herr, Wolfgang ; Giebel, Bernd ; Ruland, Jürgen ; Bassermann, Florian ; Coch, Christoph ; Hartmann, Gunther ; Poeck, Hendrik
Date of publication of this fulltext: 19 Sep 2023 10:58



Abstract

Tumor-derived extracellular vesicles (EVs) have been associated with immune evasion and tumor progression. We show that the RNA-sensing receptor RIG-I within tumor cells governs biogenesis and immunomodulatory function of EVs. Cancer-intrinsic RIG-I activation releases EVs, which mediate dendritic cell maturation and T cell antitumor immunity, synergizing with immune checkpoint blockade. Intact ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons