Targeting the microenvironment in the treatment of arteriovenous malformations

URN to cite this document:: urn:nbn:de:bvb:355-epub-547504
DOI to cite this document:: 10.5283/epub.54750

Seebauer, Caroline T. ; Wiens, Benedikt ; Hintschich, Constantin A.

; Platz Batista da Silva, Natascha

; Evert, Katja

; Haubner, Frank ; Kapp, Friedrich G. ; Wendl, Christina ; Renner, Kathrin

; Bohr, Christopher ; Kühnel, Thomas S.

; Vielsmeier, Veronika

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Sep 2023 12:20

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Abstract

Extracranial arteriovenous malformations (AVMs) are regarded as rare diseases and are prone to complications such as pain, bleeding, relentless growth, and high volume of shunted blood. Due to the high vascular pressure endothelial cells of AVMs are exposed to mechanical stress. To control symptoms and lesion growth pharmacological treatment strategies are urgently needed in addition to surgery ...