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Targeting the microenvironment in the treatment of arteriovenous malformations

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Seebauer, Caroline T. ; Wiens, Benedikt ; Hintschich, Constantin A. ; Platz Batista da Silva, Natascha ; Evert, Katja ; Haubner, Frank ; Kapp, Friedrich G. ; Wendl, Christina ; Renner, Kathrin ; Bohr, Christopher ; Kühnel, Thomas S. ; Vielsmeier, Veronika
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Date of publication of this fulltext: 25 Sep 2023 12:20

This publication is part of the DEAL contract with Springer.


Extracranial arteriovenous malformations (AVMs) are regarded as rare diseases and are prone to complications such as pain, bleeding, relentless growth, and high volume of shunted blood. Due to the high vascular pressure endothelial cells of AVMs are exposed to mechanical stress. To control symptoms and lesion growth pharmacological treatment strategies are urgently needed in addition to surgery ...


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