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Immunogenicity of a silica nanoparticle-based SARS-CoV-2 vaccine in mice

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Barbey, Clara ; Su, Jinpeng ; Billmeier, Martina ; Stefan, Nadine ; Bester, Romina ; Carnell, George ; Temperton, Nigel ; Heeney, Jonathan L. ; Protzer, Ulrike ; Breunig, Miriam ; Wagner, Ralf ; Peterhoff, David
Date of publication of this fulltext: 09 Nov 2023 12:09


Safe and effective vaccines have been regarded early on as critical in combating the COVID-19 pandemic. Among the deployed vaccine platforms, subunit vaccines have a particularly good safety profile but may suffer from a lower immunogenicity compared to mRNA based or viral vector vaccines. In fact, this phenomenon has also been observed for SARS-CoV-2 subunit vaccines comprising the ...


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