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Restrictive Versus Permissive Use of Broad-spectrum Antibiotics in Patients Receiving Allogeneic Stem Cell Transplantation and With Early Fever Due to Cytokine Release Syndrome: Evidence for Beneficial Microbiota Protection Without Increase in Infectious Complications

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Weber, Daniela ; Hiergeist, Andreas ; Weber, Markus ; Ghimire, Sakhila ; Salzberger, Bernd ; Wolff, Daniel ; Poeck, Hendrik ; Gessner, André ; Edinger, Matthias ; Herr, Wolfgang ; Meedt, Elisabeth ; Holler, Ernst
Date of publication of this fulltext: 20 Nov 2023 12:11


Abstract Background Intestinal microbiome contributes to the pathophysiology of acute gastrointestinal (GI) graft-versus-host disease (GvHD) and loss of microbiome diversity influences the outcome of patients after allogeneic stem cell transplantation (SCT). Systemic broad-spectrum antibiotics have been identified as a major cause of early intestinal dysbiosis. Methods In 2017, our ...


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