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Novel T cell/organoid culture system allows ex vivo modeling of intestinal graft-versus-host disease

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Matthe, Diana M. ; Dinkel, Martin ; Schmid, Benjamin ; Vogler, Tina ; Neurath, Markus F. ; Poeck, Hendrik ; Neufert, Clemens ; Büttner-Herold, Maike ; Hildner, Kai
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Date of publication of this fulltext: 21 Nov 2023 14:45


Acute graft-versus-host disease (GvHD) remains the biggest clinical challenge and prognosis-determining complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Donor T cells are acceptedly key mediators of alloreactivity against host tissues and here especially the gut. In support of previous studies, we found that the intestinal intra-epithelial lymphocyte (IEL) ...


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