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Domański, Michał ; Marcou, Gilles ; Barham, Joshua P.

An affordable, programmable and interactive continuous flow Photoreactor setup for undergraduate organic synthetic teaching labs

Domański, Michał , Marcou, Gilles und Barham, Joshua P. (2024) An affordable, programmable and interactive continuous flow Photoreactor setup for undergraduate organic synthetic teaching labs. Journal of Flow Chemistry 14, S. 349-355.

Veröffentlichungsdatum dieses Volltextes: 23 Jan 2024 11:59
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.55402


Zusammenfassung

Photochemistry and continuous flow chemistry are synthetic technology platforms that have witnessed an increasing uptake by chemical industries interested in complex organic molecule synthesis. Simultaneously, automation and data science are prominent targets in organic synthesis and in chemical industries for streamlined workflows, meaning hardware-software interaction between operators and ...

Photochemistry and continuous flow chemistry are synthetic technology platforms that have witnessed an increasing uptake by chemical industries interested in complex organic molecule synthesis. Simultaneously, automation and data science are prominent targets in organic synthesis and in chemical industries for streamlined workflows, meaning hardware-software interaction between operators and devices is crucial. Since undergraduate teaching labs at public-funded research Universities typically (i) lack budget for commercial, user-friendly continuous flow reactors and (ii) do not teach synthetic chemists how to program or interact with reactors, there is a disparity between the skills undergraduates are equipped with and the skills that future industries need. We report a teaching lab project where undergraduates assemble, program and execute a continuous flow photoreactor to realize a multigram-scale photoredox catalyzed oxidation reaction. A palladium-free synthetic access to the starting material was described to further cut costs. Not only does this exercise introduce useful skills in reactor design, programming and wet chemistry (both photochemical and thermal, both batch and flow), it also accommodates both the typical budget and afternoon timeslot (2-3 h) of a teaching lab and can be followed by thin-layer chromatography/color changes without necessarily requiring access to NMR facilities.



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Details

DokumentenartArtikel
Titel eines Journals oder einer ZeitschriftJournal of Flow Chemistry
Verlag:Springer Nature
Band:14
Seitenbereich:S. 349-355
Datum18 Januar 2024
InstitutionenChemie und Pharmazie > Institut für Organische Chemie
Identifikationsnummer
WertTyp
10.1007/s41981-023-00306-9DOI
Stichwörter / KeywordsContinuous flow · Photochemistry · Teaching labs · Programming · Organic synthesis
Dewey-Dezimal-Klassifikation500 Naturwissenschaften und Mathematik > 540 Chemie
StatusVeröffentlicht
BegutachtetJa, diese Version wurde begutachtet
An der Universität Regensburg entstandenZum Teil
URN der UB Regensburgurn:nbn:de:bvb:355-epub-554020
Dokumenten-ID55402

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