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An affordable, programmable and interactive continuous flow Photoreactor setup for undergraduate organic synthetic teaching labs
Domański, Michał
, Marcou, Gilles und Barham, Joshua P.
(2024)
An affordable, programmable and interactive continuous flow Photoreactor setup for undergraduate organic synthetic teaching labs.
Journal of Flow Chemistry 14, S. 349-355.
Veröffentlichungsdatum dieses Volltextes: 23 Jan 2024 11:59
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.55402
Zusammenfassung
Photochemistry and continuous flow chemistry are synthetic technology platforms that have witnessed an increasing uptake by chemical industries interested in complex organic molecule synthesis. Simultaneously, automation and data science are prominent targets in organic synthesis and in chemical industries for streamlined workflows, meaning hardware-software interaction between operators and ...
Photochemistry and continuous flow chemistry are synthetic technology platforms that have witnessed an increasing uptake by chemical industries interested in complex organic molecule synthesis. Simultaneously, automation and data science are prominent targets in organic synthesis and in chemical industries for streamlined workflows, meaning hardware-software interaction between operators and devices is crucial. Since undergraduate teaching labs at public-funded research Universities typically (i) lack budget for commercial, user-friendly continuous flow reactors and (ii) do not teach synthetic chemists how to program or interact with reactors, there is a disparity between the skills undergraduates are equipped with and the skills that future industries need. We report a teaching lab project where undergraduates assemble, program and execute a continuous flow photoreactor to realize a multigram-scale photoredox catalyzed oxidation reaction. A palladium-free synthetic access to the starting material was described to further cut costs. Not only does this exercise introduce useful skills in reactor design, programming and wet chemistry (both photochemical and thermal, both batch and flow), it also accommodates both the typical budget and afternoon timeslot (2-3 h) of a teaching lab and can be followed by thin-layer chromatography/color changes without necessarily requiring access to NMR facilities.
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Details
| Dokumentenart | Artikel | ||||
| Titel eines Journals oder einer Zeitschrift | Journal of Flow Chemistry | ||||
| Verlag: | Springer Nature | ||||
|---|---|---|---|---|---|
| Band: | 14 | ||||
| Seitenbereich: | S. 349-355 | ||||
| Datum | 18 Januar 2024 | ||||
| Institutionen | Chemie und Pharmazie > Institut für Organische Chemie | ||||
| Identifikationsnummer |
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| Stichwörter / Keywords | Continuous flow · Photochemistry · Teaching labs · Programming · Organic synthesis | ||||
| Dewey-Dezimal-Klassifikation | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status | Veröffentlicht | ||||
| Begutachtet | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden | Zum Teil | ||||
| URN der UB Regensburg | urn:nbn:de:bvb:355-epub-554020 | ||||
| Dokumenten-ID | 55402 |
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