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Domański, Michał ; Marcou, Gilles ; Barham, Joshua P.

An affordable, programmable and interactive continuous flow Photoreactor setup for undergraduate organic synthetic teaching labs

Domański, Michał , Marcou, Gilles and Barham, Joshua P. (2024) An affordable, programmable and interactive continuous flow Photoreactor setup for undergraduate organic synthetic teaching labs. Journal of Flow Chemistry 14, pp. 349-355.

Date of publication of this fulltext: 23 Jan 2024 11:59
Article
DOI to cite this document: 10.5283/epub.55402


Abstract

Photochemistry and continuous flow chemistry are synthetic technology platforms that have witnessed an increasing uptake by chemical industries interested in complex organic molecule synthesis. Simultaneously, automation and data science are prominent targets in organic synthesis and in chemical industries for streamlined workflows, meaning hardware-software interaction between operators and ...

Photochemistry and continuous flow chemistry are synthetic technology platforms that have witnessed an increasing uptake by chemical industries interested in complex organic molecule synthesis. Simultaneously, automation and data science are prominent targets in organic synthesis and in chemical industries for streamlined workflows, meaning hardware-software interaction between operators and devices is crucial. Since undergraduate teaching labs at public-funded research Universities typically (i) lack budget for commercial, user-friendly continuous flow reactors and (ii) do not teach synthetic chemists how to program or interact with reactors, there is a disparity between the skills undergraduates are equipped with and the skills that future industries need. We report a teaching lab project where undergraduates assemble, program and execute a continuous flow photoreactor to realize a multigram-scale photoredox catalyzed oxidation reaction. A palladium-free synthetic access to the starting material was described to further cut costs. Not only does this exercise introduce useful skills in reactor design, programming and wet chemistry (both photochemical and thermal, both batch and flow), it also accommodates both the typical budget and afternoon timeslot (2-3 h) of a teaching lab and can be followed by thin-layer chromatography/color changes without necessarily requiring access to NMR facilities.



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Details

Item typeArticle
Journal or Publication TitleJournal of Flow Chemistry
Publisher:Springer Nature
Volume:14
Page Range:pp. 349-355
Date18 January 2024
InstitutionsChemistry and Pharmacy > Institut für Organische Chemie
Identification Number
ValueType
10.1007/s41981-023-00306-9DOI
KeywordsContinuous flow · Photochemistry · Teaching labs · Programming · Organic synthesis
Dewey Decimal Classification500 Science > 540 Chemistry & allied sciences
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgPartially
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-554020
Item ID55402

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