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Addressing Genetic Tumor Heterogeneity, Post-Therapy Metastatic Spread, Cancer Repopulation, and Development of Acquired Tumor Cell Resistance

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Harrer, Dennis Christoph ; Lüke, Florian ; Pukrop, Tobias ; Ghibelli, Lina ; Reichle, Albrecht ; Heudobler, Daniel
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Date of publication of this fulltext: 26 Jan 2024 16:56


The concept of post-therapy metastatic spread, cancer repopulation and acquired tumor cell resistance (M-CRAC) rationalizes tumor progression because of tumor cell heterogeneity arising from post-therapy genetic damage and subsequent tissue repair mechanisms. Therapeutic strategies designed to specifically address M-CRAC involve tissue editing approaches, such as low-dose metronomic ...


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