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The Colorectal Cancer Lipidome: Identification of a Robust Tumor-Specific Lipid Species Signature

Ecker, Josef ; Benedetti, Elisa ; Kindt, Alida S.D. ; Höring, Marcus ; Perl, Markus ; Machmüller, Andrea Christel ; Sichler, Anna ; Plagge, Johannes ; Wang, Yuting ; Zeissig, Sebastian ; Shevchenko, Andrej ; Burkhardt, Ralph ; Krumsiek, Jan ; Liebisch, Gerhard ; Janssen, Klaus-Peter



Abstract

OBJECTIVE: Lipidomic changes were causally linked to meta-bolic diseases, but the scenario for colorectal cancer (CRC) is less clear. We investigated the CRC lipidome for putative tumor-specific alterations through analysis of 3 independent retrospective patient cohorts from 2 clinical centers, to derive a clinically useful signature. DESIGN: Quantitative comprehen-sive lipidomic analysis was ...

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