Systematic Evaluation of Fluorination as Modification for Peptide‐Based Fusion Inhibitors against HIV‐1 Infection

URN to cite this document:: urn:nbn:de:bvb:355-epub-564892
DOI to cite this document:: 10.5283/epub.56489

Huhmann, Susanne

; Nyakatura, Elisabeth K. ; Rohrhofer, Anette ; Moschner, Johann ; Schmidt, Barbara

; Eichler, Jutta

; Roth, Christian ; Koksch, Beate

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 29 Feb 2024 12:28

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Abstract

With the emergence of novel viruses, the development of new antivirals is more urgent than ever. A key step in human immunodeficiency virus type 1 (HIV-1) infection is six-helix bundle formation within the envelope protein subunit gp41. Selective disruption of bundle formation by peptides has been shown to be effective; however, these drugs, exemplified by T20, are prone to rapid clearance from ...