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Poor humoral and T-cell response to two-dose SARS-CoV-2 messenger RNA vaccine BNT162b2 in cardiothoracic transplant recipients

Schramm, René ; Costard-Jäckle, Angelika ; Rivinius, Rasmus ; Fischer, Bastian ; Müller, Benjamin ; Boeken, Udo ; Haneya, Assad ; Provaznik, Zdenek ; Knabbe, Cornelius ; Gummert, Jan


Aims Immunocompromised patients have been excluded from studies of SARS-CoV-2 messenger RNA vaccines. The immune response to vaccines against other infectious agents has been shown to be blunted in such patients. We aimed to analyse the humoral and cellular response to prime-boost vaccination with the BNT162b2 vaccine (Pfizer-BioNTech) in cardiothoracic transplant recipients. Methods and results ...


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