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Quantitative analysis of liver function: 3D variable-flip-angle versus Look-Locker T1 relaxometry in hepatocyte-specific contrast-enhanced liver MRI

Verloh, Niklas ; Fuhrmann, Irene ; Fellner, Claudia ; Nickel, Dominik ; Zeman, Florian ; Kandulski, Arne ; Hornung, Matthias ; Stroszczynski, Christian ; Wiggermann, Philipp ; Haimerl, Michael


Background: Gd-EOB-DTPA, a liver specific contrast agent with T1- shortening effects, is routinely used in clinical magnetic resonance imaging (MRI) for detection and characterization of focal liver lesions. Gd-EOB-DTPA-enhanced T1 relaxometry has recently received increasing attention as a tool for the quantitative analyses of liver function. However, this T1 relaxometry technique is limited due ...


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