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Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence

Noth, J. ; Frankowski, K. J. ; Neuenswander, B. ; Aube, J. ; Reiser, O.


A three-component method for the synthesis of highly substituted gamma-lactams from readily available maleimides, aldehydes, and amines is described. A new reductive amination/intramolecular lactamization sequence provides a straightforward route to the lactam products in a single manipulation. The general utility of this method is demonstrated by the parallel synthesis of a gamma-lactam library.

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