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Prognostic and Predictive Value of Fibroblast Growth Factor Receptor Alterations in High-grade Non–muscle-invasive Bladder Cancer Treated with and Without Bacillus Calmette-Guérin Immunotherapy

Mayr, Roman ; Eckstein, Markus ; Wirtz, Ralph M. ; Santiago-Walker, Ademi ; Baig, Mahadi ; Sundaram, Ramesh ; Carcione, Jenna Cody ; Stoehr, Robert ; Hartmann, Arndt ; Bolenz, Christian ; Burger, Maximilian ; Otto, Wolfgang ; Erben, Philipp ; Breyer, Johannes


Background: Limited data are available on the prognostic and predictive value of fibroblast growth factor receptor alterations (FGFRa) relative to clinical outcomes in patients with non-muscle-invasive bladder cancer (NMIBC).Objective: To determine whether FGFRa may be clinically useful in stratifying for treatment response in a real-world cohort of patients with pT1 NMIBC treated and untreated ...


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