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Prognostic markers in invasive bladder cancer: FGFR3 mutation status versus P53 and KI-67 expression: a multi-center, multi-laboratory analysis in 1058 radical cystectomy patients

Mertens, Laura S. ; Claps, Francesco ; Mayr, Roman ; Bostrom, Peter J. ; Shariat, Shahrokh F. ; Zwarthoff, Ellen C. ; Boormans, Joost L. ; Abas, Cheno ; van Leenders, Geert J.L.H. ; Götz, Stefanie ; Hippe, Katrin ; Bertz, Simone ; Neuzillet, Yann ; Sanders, Joyce ; Broeks, Annegien ; Peters, Dennis ; van der Heijden, Michiel S. ; Jewett, Michael A.S. ; Stöhr, Robert ; Zlotta, Alexandre R. ; Eckstein, Markus ; Soorojebally, Yanish ; van der Schoot, Deric K.E. ; Wullich, Bernd ; Burger, Maximilian ; Otto, Wolfgang ; Radvanyi, François ; Sirab, Nanour ; Pouessel, Damien ; van der Kwast, Theo H. ; Hartmann, Arndt ; Lotan, Yair ; Allory, Yves ; Zuiverloon, Tahlita C.M. ; van Rhijn, Bas W.G.



Abstract

Objectives: To determine the association between the FGFR3 mutation status and immuno-histochemistry (IHC) markers (p53 and Ki-67) in invasive bladder cancer (BC), and to analyze their prognostic value in a multicenter, multi-laboratory radical cystectomy (RC) cohort. Patients and methods: We included 1058 cN0M0, chemotherapy-naive BC patients who underwent RC with pelvic lymph-node dissection at ...

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