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Disease Progression of Hypertrophic Cardiomyopathy: Modeling Using Machine Learning

Pičulin, Matej ; Smole, Tim ; Žunkovič, Bojan ; Kokalj, Enja ; Robnik-Šikonja, Marko ; Kukar, Matjaž ; Fotiadis, Dimitrios I ; Pezoulas, Vasileios C ; Tachos, Nikolaos S ; Barlocco, Fausto ; Mazzarotto, Francesco ; Popović, Dejana ; Maier, Lars S ; Velicki, Lazar ; Olivotto, Iacopo ; MacGowan, Guy A ; Jakovljević, Djordje G ; Filipović, Nenad ; Bosnić, Zoran


Background: Cardiovascular disorders in general are responsible for 30% of deaths worldwide. Among them, hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease that is present in about 1 of 500 young adults and can cause sudden cardiac death (SCD). Objective: Although the current state-of-the-art methods model the risk of SCD for patients, to the best of our knowledge, no methods are ...


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