Dokumentenart: | Artikel | ||||
---|---|---|---|---|---|
Titel eines Journals oder einer Zeitschrift: | Human Molecular Genetics | ||||
Verlag: | OXFORD UNIV PRESS | ||||
Ort der Veröffentlichung: | OXFORD | ||||
Band: | 31 | ||||
Nummer des Zeitschriftenheftes oder des Kapitels: | 23 | ||||
Seitenbereich: | S. 3945-3966 | ||||
Datum: | 2022 | ||||
Institutionen: | Medizin > Lehrstuhl für Neurologie Medizin > Abteilung für Krankenhaushygiene und Infektiologie | ||||
Identifikationsnummer: |
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Stichwörter / Keywords: | GENOME; ASSOCIATION; INVERSION; IMPUTATION; SELECTION; SYSTEM; | ||||
Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Ja | ||||
Dokumenten-ID: | 57800 |
Zusammenfassung
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12488 ...
Zusammenfassung
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a similar to 0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.
Metadaten zuletzt geändert: 29 Feb 2024 13:02