Cytokine Response of Natural Killer Cells to Hepatitis B Virus Infection Depends on Monocyte Co-Stimulation

URN to cite this document:: urn:nbn:de:bvb:355-epub-582730
DOI to cite this document:: 10.5283/epub.58273

Kupke, Paul

; Brucker, Johanna ; Wettengel, Jochen M. ; Protzer, Ulrike

; Wenzel, Jürgen J.

; Schlitt, Hans J.

; Geissler, Edward K.

; Werner, Jens M.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 14 May 2024 13:50

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Abstract

Hepatitis B virus (HBV) is a major driver of chronic hepatic inflammation, which regularly leads to liver cirrhosis or hepatocellular carcinoma. Immediate innate immune cell response is crucial for the rapid clearance of the infection. Here, natural killer (NK) cells play a pivotal role in direct cytotoxicity and the secretion of antiviral cytokines as well as regulatory function. The aim of this ...