Magnetic CAR T cell purification using an anti-G4S linker antibody

URN to cite this document:: urn:nbn:de:bvb:355-epub-582956
DOI to cite this document:: 10.5283/epub.58295

Harrer, Dennis Christoph

; Li, Sin-Syue ; Kaljanac, Marcell ; Bezler, Valerie ; Barden, Markus ; Pan, Hong ; Herr, Wolfgang ; Abken, Hinrich

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 May 2024 06:35

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Abstract

Chimeric antigen receptor (CAR) redirected T cells are successfully employed in the combat against several hematological malignancies, however, are often compromised by low transduction rates making refinement of the CAR T cell products necessary. Here, we report a broadly applicable enrichment protocol relying on marking CAR T cells with an anti-glycine4-serine (G4S) linker antibody followed by ...