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Donor regulatory T cells rapidly adapt to recipient tissues to control murine acute graft-versus-host disease

URN to cite this document:
urn:nbn:de:bvb:355-epub-583453
DOI to cite this document:
10.5283/epub.58345
Dittmar, David Jonathan ; Pielmeier, Franziska ; Strieder, Nicholas ; Fischer, Alexander ; Herbst, Michael ; Stanewsky, Hanna ; Wenzl, Niklas ; Röseler, Eveline ; Eder, Rüdiger ; Gebhard, Claudia ; Schwarzfischer-Pfeilschifter, Lucia ; Albrecht, Christian ; Herr, Wolfgang ; Edinger, Matthias ; Hoffmann, Petra ; Rehli, Michael
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 28 May 2024 08:29



Abstract

The adoptive transfer of regulatory T cells is a promising strategy to prevent graft-versus-host disease after allogeneic bone marrow transplantation. Here, we use a major histocompatibility complex-mismatched mouse model to follow the fate of in vitro expanded donor regulatory T cells upon migration to target organs. Employing comprehensive gene expression and repertoire profiling, we show that ...

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