Protodefluorinated Selectfluor® Aggregatively Activates Selectfluor® for Efficient Radical C(sp3)−H Fluorination Reactions

URN to cite this document:: urn:nbn:de:bvb:355-epub-585186
DOI to cite this document:: 10.5283/epub.58518

Yakubov, S. ; Dauth, B. ; Stockerl, W. J. ; Menezes da Silva, W. ; Gschwind, R. M.

; Barham, Joshua Philip

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Jun 2024 05:25

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Abstract

Efficient fluorination reactions are key in the late-stage functionalization of complex molecules in medicinal chemistry, in upgrading chemical feedstocks, and in materials science. Radical C(sp3)−H fluorinations using Selectfluor® - one of the most popular fluorination agents - allow to directly engage unactivated precursors under mild photochemical or thermal catalytic conditions. However, ...