Attenuated and Protease-Profile Modified Sendai Virus Vectors as a New Tool for Virotherapy of Solid Tumors

URN to cite this document:: urn:nbn:de:bvb:355-epub-588865
DOI to cite this document:: 10.5283/epub.58886

Takimoto, Toru ; Zimmermann, Martina ; Armeanu-Ebinger, Sorin ; Bossow, Sascha ; Lampe, Johanna ; Smirnow, Irina ; Schenk, Andrea

; Lange, Sebastian

; Weiss, Thomas S. ; Neubert, Wolfgang ; Lauer, Ulrich M. ; Bitzer, Michael

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Aug 2024 13:26

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Abstract

Multiple types of oncolytic viruses are currently under investigation in clinical trials. To optimize therapeutic outcomes it is believed that the plethora of different tumor types will require a diversity of different virus types. Sendai virus (SeV), a murine parainfluenza virus, displays a broad host range, enters cells within minutes and already has been applied safely as a gene transfer ...