Novel Inhibitors of Cyclin-Dependent Kinases Combat Hepatocellular Carcinoma without Inducing Chemoresistance

URN to cite this document:: urn:nbn:de:bvb:355-epub-588980
DOI to cite this document:: 10.5283/epub.58898

Haider, Christine ; Grubinger, Markus ; Řezníčková, Eva ; Weiss, Thomas S.

; Rotheneder, Hans ; Miklos, Walter ; Berger, Walter ; Jorda, Radek ; Zatloukal, Marek ; Gucký, Tomáš ; Strnad, Miroslav ; Kryštof, Vladimír ; Mikulits, Wolfgang

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Date of publication of this fulltext: 16 Aug 2024 05:49

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Abstract

Abstract Treatment options for hepatocellular carcinoma using chemotherapeutics at intermediate and advanced stages of disease are limited as patients most rapidly escape from therapy and succumb to disease progression. Mechanisms of the hepatic xenobiotic metabolism are mostly involved in providing chemoresistance to therapeutic compounds. Given the fact that the aberrant activation of ...