Selective Protection of Human Liver Tissue in TNF-Targeting of Cancers of the Liver by Transient Depletion of Adenosine Triphosphate

URN to cite this document:: urn:nbn:de:bvb:355-epub-589126
DOI to cite this document:: 10.5283/epub.58912

Haybaeck, Johannes ; Weiland, Timo ; Klein, Kathrin ; Zimmermann, Martina ; Speicher, Tobias ; Venturelli, Sascha ; Berger, Alexander ; Bantel, Heike ; Königsrainer, Alfred ; Schenk, Martin

; Weiss, Thomas S. ; Wendel, Albrecht ; Schwab, Matthias ; Bitzer, Michael ; Lauer, Ulrich M.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 16 Aug 2024 09:41

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Abstract

Background: Tumor necrosis factor alpha (TNF) is able to kill cancer cells via receptor-mediated cell death requiring adenosine triphosphate (ATP). Clinical usage of TNF so far is largely limited by its profound hepatotoxicity. Recently, it was found in the murine system that specific protection of hepatocytes against TNF's detrimental effects can be achieved by fructose-mediated ATP depletion ...

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