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Soluble CD163 is not increased in visceral fat and steatotic liver and is even suppressed by free fatty acids in vitro

Bauer, Sabrina ; Weiss, Thomas S. ; Wiest, Reiner ; Schacherer, Doris ; Hellerbrand, Claus ; Farkas, Stefan ; Scherer, Marcus N. ; Ritter, Mirko ; Schmitz, Gerd ; Schäffler, Andreas ; Buechler, Christa




Abstract

Abstract Visceral fat differs from subcutaneous fat by higher local inflammation and increased release of IL-6 and free fatty acids (FFA) which contribute to hepatic steatosis. IL-6 has been shown to upregulate the monocyte/macrophage specific receptor CD163 whose soluble form, sCD163, is increased in inflammatory diseases. Here, it was analyzed whether CD163 and sCD163 are differentially ...

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