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Primary Human Hepatocytes as an in vitro Model for Hepatitis B Virus Infection

Boehm, Stephan ; Thasler, Wolfgang E. ; Weiss, Thomas S. ; Jilg, Wolfgang




Abstract

Hepatitis B virus (HBV) represents the prototypic member of the genus Orthohepadnavirus within the family Hepadnaviridae, which forms a group of small enveloped DNA viruses with the typical biological features of high species specificity and hepatotropism. Animal models used for in vivo and in vitro infection experiments have been established for the hepadnavirus species of the woodchuck, ...

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