Ectopic PU.1 Expression Provides Chimeric Antigen Receptor (CAR) T Cells with Innate Cell Capacities Including IFN-β Release

URN to cite this document:: urn:nbn:de:bvb:355-epub-590619
DOI to cite this document:: 10.5283/epub.59061

Harrer, Dennis Christoph

; Eder, Matthias ; Barden, Markus ; Pan, Hong ; Herr, Wolfgang ; Abken, Hinrich

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 04 Sep 2024 08:22

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Abstract

Chimeric antigen receptor (CAR) T cell therapy has achieved extraordinary success in eliminating B cell malignancies; however, so far, it has shown limited efficacy in the treatment of solid tumors, which is thought to be due to insufficient CAR T cell activation. We hypothesized that the transcription factor PU.1, a master regulator of innate cell functionality, may augment ...