Increased PD‐1/PD‐L1 Immune Checkpoint Expression Is Associated With Oral Squamous Cell Carcinoma in Never‐Smokers and Never‐Drinkers

URN to cite this document:: urn:nbn:de:bvb:355-epub-594512
DOI to cite this document:: 10.5283/epub.59451

Fiedler, Mathias

; Off, Alisa ; Gärtner, Andreas ; Brockhoff, Gero

; Eichberger, Jonas ; Gottsauner, Maximilian ; Schuderer, Johannes G.

; Maurer, Michael

; Bauer, Richard J.

; Gerken, Michael ; Reichert, Torsten E. ; Ettl, Tobias

; Weber, Florian

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 29 Oct 2024 12:19

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Abstract

Background This study aimed to explore the disparities in PD-1 and PD-L1 expression among oral squamous cell carcinomas (OSCCs) in individuals categorized as never-smokers/never-drinkers versus smokers/drinkers. Methods Immunohistochemical staining for PD-1 and PD-L1, along with PDCD1LG2/cen9 dual color probe analysis, was conducted on 130 OSCC specimens from both smoker/drinker and ...