Stammler, Dominik ; Eigenbrod, Tatjana ; Menz, Sarah ; Frick, Julia S. ; Sweet, Matthew J. 
; Shakespear, Melanie R. ; Jantsch, Jonathan ; Siegert, Isabel ; Wölfle, Sabine ; Langer, Julian D. ; Oehme, Ina ; Schaefer, Liliana ; Fischer, Andre ; Knievel, Judith ; Heeg, Klaus ; Dalpke, Alexander H. ; Bode, Konrad A.
; Shakespear, Melanie R. ; Jantsch, Jonathan ; Siegert, Isabel ; Wölfle, Sabine ; Langer, Julian D. ; Oehme, Ina ; Schaefer, Liliana ; Fischer, Andre ; Knievel, Judith ; Heeg, Klaus ; Dalpke, Alexander H. ; Bode, Konrad A. 
Abstract
Histone deacetylase (HDAC) inhibitors (HDACi) are clinically approved anticancer drugs that have important immunemodulatory properties. We report the surprising finding that HDACi promote LPS-induced IL-1 beta processing and secretion in human and murine dendritic cells and murine macrophages. HDACi/LPS-induced IL-1 beta maturation and secretion kinetics differed completely from those observed ...
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