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An atlas of active enhancers across human cell types and tissues

Andersson, Robin ; Gebhard, Claudia ; Miguel-Escalada, Irene ; Hoof, Ilka ; Bornholdt, Jette ; Boyd, Mette ; Chen, Yun ; Zhao, Xiaobei ; Schmidl, Christian ; Suzuki, Takahiro ; Ntini, Evgenia ; Arner, Erik ; Valen, Eivind ; Li, Kang ; Schwarzfischer, Lucia ; Glatz, Dagmar ; Raithel, Johanna ; Lilje, Berit ; Rapin, Nicolas ; Bagger, Frederik Otzen ; Jørgensen, Mette ; Andersen, Peter Refsing ; Bertin, Nicolas ; Rackham, Owen ; Burroughs, A. Maxwell ; Baillie, J. Kenneth ; Ishizu, Yuri ; Shimizu, Yuri ; Furuhata, Erina ; Maeda, Shiori ; Negishi, Yutaka ; Mungall, Christopher J. ; Meehan, Terrence F. ; Lassmann, Timo ; Itoh, Masayoshi ; Kawaji, Hideya ; Kondo, Naoto ; Kawai, Jun ; Lennartsson, Andreas ; Daub, Carsten O. ; Heutink, Peter ; Hume, David A. ; Jensen, Torben Heick ; Suzuki, Harukazu ; Hayashizaki, Yoshihide ; Müller, Ferenc ; Forrest, Alistair R. R. ; Carninci, Piero ; Rehli, Michael ; Sandelin, Albin



Abstract

Enhancers control the correct temporal and cell-type-specific activation of gene expression in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial to understand the regulation of differentiation and homeostasis. Here we use the FANTOM5 panel of samples, covering the majority of human tissues and cell types, to produce an atlas of active, in ...

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