| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Clinical Breast Cancer | ||||
| Publisher: | CIG MEDIA GROUP, LP | ||||
| Place of Publication: | DALLAS | ||||
| Volume: | 14 | ||||
| Number of Issue or Book Chapter: | 1 | ||||
| Page Range: | pp. 40-45 | ||||
| Date: | 2014 | ||||
| Institutions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) | ||||
| Identification Number: |
| ||||
| Keywords: | RANDOMIZED CLINICAL-TRIAL; INTRAOPERATIVE ULTRASOUND; MARGIN STATUS; RADIATION-THERAPY; RE-EXCISION; FOLLOW-UP; STAGE-I; LUMPECTOMY; LOCALIZATION; MASTECTOMY; Breast-conserving surgery; Breast cancer; Tumorectomy; Ultrasound; Ultrasonography | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 61778 |
Web of ScienceAbstract
We investigated the efficacy of ultrasonography-guided breast-conserving surgery in 335 women with palpable palpation-guided excision in predicting the closest margins, obtaining clear surgical margins, and reducing re-operations. Introduction: The aim of this study was to determine the efficacy of ultrasonography (US)-guided excision of palpable breast cancer and to compare it with the standard ...
Abstract
We investigated the efficacy of ultrasonography-guided breast-conserving surgery in 335 women with palpable palpation-guided excision in predicting the closest margins, obtaining clear surgical margins, and reducing re-operations. Introduction: The aim of this study was to determine the efficacy of ultrasonography (US)-guided excision of palpable breast cancer and to compare it with the standard palpation-guided breast-conserving surgery (BCS). Methods: For this purpose, 335 women with palpable breast cancer who underwent BCS were retrospectively studied. The positive surgical margins and re-excision rates were investigated. Results: Of the total cohort, 137 patients were treated with palpation-guided BCS and 198 underwent US-guided tumor excision. The tumor and patient characteristics were similar in both groups. Patient age, postmenopausal status, tumor size, histological grade, intraductal tumor component, lobular histology, and palpation-guided tumor excision were associated with increased risk of positive margins. The shave margins were re-excised at the time of original operation more often by palpation-guided localization (28.5%) than by the US-guided procedure (11.1%) (P < .0001). A surgeon was able to correctly identify the "problematic" margin in 81.1% of cases via intraoperative US and in only 17.9% via palpation (P < .0001). The re-excision rate during a second operation was significantly reduced by US-guided tumorectomy (P = .004). Of 198 patients in the US-guided group, 23 (11.6%) underwent a second operation, as did 33 of 137 patients in the palpation group (24.1%). The sensitivity and specificity of US-guided excisions were 52.7% and 97.5%, respectively, whereas the sensitivity and the specificity of palpation-guided tumor excisions were 15.5% and 65.9%, respectively. Conclusion: US-guided BCS is superior to palpation-guided excision in predicting the closest margins, obtaining clear surgical margins, and reducing re-operations. (C) 2014 Elsevier Inc. All rights reserved.
Metadata last modified: 19 Dec 2024 08:13
Altmetric