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EV02: A Phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C alone

McCormack, Sheena ; Stöhr, Wolfgang ; Barber, Tristan ; Bart, Pierre-Alexandre ; Harari, Alexandre ; Moog, Christiane ; Ciuffreda, Donatella ; Cellerai, Cristina ; Cowen, Miranda ; Gamboni, Romilda ; Burnet, Séverine ; Legg, Ken ; Brodnicki, Elizabeth ; Wolf, Hans ; Wagner, Ralf ; Heeney, Jonathan ; Frachette, Marie-Joëlle ; Tartaglia, Jim ; Babiker, Abdel ; Pantaleo, Giuseppe ; Weber, Jonathan



Abstract

The aim of this randomised controlled trial was to see if the addition of 4mg/ml DNA-C priming given by the intramuscular route at weeks 0 and 4 to NYVAC-C at weeks 20 and 24, safety increased the proportion of participants with HIV-specific T-cell responses measured by the interferon (IFN)-gamma ELISpot assay at weeks 26 and/or 28 compared to NYVAC-C alone. Although 2 individuals discontinued ...

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