A Role for CD54 (Intercellular Adhesion Molecule-1) in Leukocyte Recruitment to the Lung During the Development of Experimental Idiopathic Pneumonia Syndrome

Gerbitz, Armin ; Ewing, Patricia ; Olkiewicz, Krystyna ; Willmarth, Nicole E. ; Williams, Debra ; Hildebrandt, Gerhard ; Wilke, Andrea ; Liu, Chen ; Eissner, Günther ; Andreesen, Reinhard ; Holler, Ernst ; Guo, Renfeng ; Ward, Peter A. ; Cooke, Kenneth R.

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Background. Idiopathic pneumonia syndrome (IPS) is a frequently fatal complication of allogeneic bone marrow transplantation (BMT). IPS is associated with elevated bronchoalveolar lavage (BAL) fluid levels of tumor necrosis factor-alpha and lipopolysaccharide, both of which are potent activators of endothelial cells (ECs). EC expression of the adhesion molecule CD54 (intercellular adhesion ...

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