The Tumor Metabolite 5′-Deoxy-5′Methylthioadenosine (MTA) Inhibits Maturation and T Cell-Stimulating Capacity of Dendritic Cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-745482
DOI to cite this document:: 10.5283/epub.74548

Brummer, Christina ; Singer, Katrin ; Henrich, Frederik ; Peter, Katrin

; Strobl, Carolin Dorothea

; Neueder, Bernadette ; Bruss, Christina ; Renner, Kathrin

; Pukrop, Tobias

; Herr, Wolfgang ; Aigner, Michael ; Kreutz, Marina

License: Creative Commons Attribution 4.0
PDF - Published Version
(2MB)

Date of publication of this fulltext: 20 Dec 2024 14:55

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

Metabolite accumulation in the tumor microenvironment fosters immune evasion and limits the efficiency of immunotherapeutic approaches. Methylthioadenosine phosphorylase (MTAP), which catalyzes the degradation of 5′-deoxy-5′methylthioadenosine (MTA), is downregulated in many cancer entities. Consequently, MTA accumulates in the microenvironment of MTAP-deficient tumors, where it is known to ...